From 2004 until 2017, Dr. h.c. Frank-Jürgen was CEO of the German Federal Agency for Employment and, from 2015 until 2016, he also headed the Federal Office for Migration and Refugees.
He started his professional career in the German Bundeswehr in 1972, where he was trained as an army officer and studied business administration. As company commander (parachutist), he also acted as a youth officer. As reserve officer, he was battalion commander, deputy regimental commander, and deputy in the NATO staff in Brussels with many foreign missions as well as a Deputy Inspector General of the Bundeswehr for recruitment. He currently holds the rank of a reserve colonel.
From 1985, Weise was Controller at the VDO Adolf Schindling AG and from 1989, chairman of the management at the Braunschweiger Hüttenwerk GmbH. He then served as Managing Director of the Societät für Unternehmensplanung in Frankfurt and Basel. From 1997, he was a member of the Executive Board of FAG Automobiltechnik AG in Schweinfurt and, in addition, director of human resources for the executives of the global FAG Group. Weise was co-founder, then CEO of the company Microlog Logistics AG in Frankfurt, which was later sold to the DELTON Holding of Stefan Quandt.
In 2002, he was appointed to the executive board of the German Federal Agency for Employment and was responsible for finance, human resources and information technology. In 2004, he was appointed CEO and resigned from office at the end of March 2017.
In 2010, he was head of the Commission on Structural Reform of the German Bundeswehr. At the end of 2015 until 2016, Weise also headed the Federal Office for Migration and Refugees. In 2017, he was Federal Government Commissioner for Refugee Management.
Weise is a board member of the Post-Foundation, the IZA (Institut der Zukunft der Arbeit, Institute of Labor Economics), the KPS Capital GmbH and Odewald SME II. In addition to his work as a partner at Rantum Capital GmbH, Frankfurt and the company KPS New York, he is Senator of the Deutsche Nationalstiftung (German National Foundation), Chairman of the Board of the non-profit Hertie Foundation and Honorary President of the Johanniter-Unfall-Hilfe.